ORGAN TRANSPLANT

Made partially possible by the PLN Foundation, a worldwide joint venture has been started under the leadership of the UMCU (the Netherlands) and the university of Pennsylvania (USA) in order to improve the outcomes of organ transplants.

Worldwide genetic research on organ transplant bundling

Research Institutes from 12 countries gather the DNA data in this study of all patients who have undergone a transplant of a kidney, heart, liver or lung.

Under the name iGeneTRAiN (International Genetics & Translational Research in Transplantation Network), the researchers are looking to trace mechanisms that cause rejection or poor functioning of organs.

Since the year 2000, more than 1,000,000 transplants have been performed globally. Despite improved surgery and more effective medication, the risk of rejection of a new organ is still high.

Approximately 60% of the patients show indications for rejection of the transplanted organ in the short and in the long term.

The research of the iGeneTRAiN consortium currently contains 36 studies from 12 countries. More than 31,000 samples have been taken and approximately 800,000 genetic variations have been measured in total (derived from gene and chromosome).

The great fact is that we have data about the DNA of receivers and of donors and that we are now able to compare these on a larger scale. That is truly unique!…”, says Prof. Dr. F. Asselbergs, Cardiovascular Genetics Professor at the Cardiac & Vascular Center of the UMCU (Netherlands) and one of the research Directors of iGeneTRAiN.

 

MORE about all PLN related research projects? Please check out the website of our PLN Foundation.

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