In order to make our heart beat, calcium ions that flow in and out of the myocardial cells, are very important.
Heart disease is caused by a loss of cardiomyocytes (heart muscle cells), usually because of a heart attack or weakening of the cardiac muscle cells. Heart contractions and the ability to pump blood through our bodies depend on well orchestrated calcium movements in and out of the cell. The PLN (phospholamban) gene is a key regulator of the pump that controls calcium cycling. Scientific names for this PLN gene mutation are c.40_42del AGA and p.Arg14del. (more…)
The 4th PLN Info Day was held at UMC Groningen on Saturday 3 November. Over two hundred people, PLN carriers, family and friends came to Groningen this afternoon. One hundred of them donated blood that will be used to do research on the PLN mutation. (more...Read More
When suffering from serious heart failure, some patients get to a point after a long disease process at which the treatment method with drugs reaches a "dead end". The heart is so sick by then and has already lost so much of its pumping strength that the pa...Read More