In order to make our heart beat, calcium ions that flow in and out of the myocardial cells, are very important.
Heart disease is caused by a loss of cardiomyocytes (heart muscle cells), usually because of a heart attack or weakening of the cardiac muscle cells. Heart contractions and the ability to pump blood through our bodies depend on well orchestrated calcium movements in and out of the cell. The PLN (phospholamban) gene is a key regulator of the pump that controls calcium cycling. Scientific names for this PLN gene mutation are c.40_42del AGA and p.Arg14del. (more…)
When suffering from serious heart failure, some patients get to a point after a long disease process at which the treatment method with drugs reaches a "dead end". The heart is so sick by then and has already lost so much of its pumping strength that the pa...Read More
Please find below a number of publications to other websites which are directly or indirectly related to PLN research projects, heart failure, heart muscle diseases etc. So please take a look at these interesting Hot-off-the-Press articles we like to (more&he...Read More
The transatlantic project The PLN disease is a currently uncurable heart muscle disease caused by a genetic mutation in the DNA. Carriers of this mutation are exposed to a major health risk which may express itself in moderate to very serious heart failure, a...Read More